Miranda R Jr, Treloar Padovano H, Gray JC, Wemm SE, Blanchard A
Addict Behav. pii: S0306-4603(18)30013-3. doi: 10.1016/j.addbeh.2018.01.009
This secondary data analysis examined whether and how the dopamine receptor D4 gene (DRD4) influenced naltrexone treatment responsiveness in a randomized clinical trial. We leveraged intensive experience sampling methods to test the hypothesis that craving recorded at drinking and non-drinking moments would mediate naltrexone effects on the likelihood of heavy drinking, but only among carriers of the DRD4 long (DRD4-L) allele.