van Nierop M, Lecei A, Myin-Germeys I, Collip D, Viechtbauer W, Jacobs N, Derom C, Thiery E, van Os J, van Winkel R
Psychiatry Res.;260:451-457. doi: 10.1016/j.psychres.2017.12.012
Childhood trauma exposure has been associated with a clinically relevant mixed phenotype of psychopathology composed of depressive, anxiety, and psychosis symptoms, across healthy and clinical samples. Altered stress-reactivity after exposure to childhood trauma may be a plausible underlying mechanism explaining this association. In a general population sample of female twins (T0 = 564; T1 = 483), associations between childhood trauma exposure and symptom profile (no symptoms, isolated symptoms, or a mixed phenotype) on the one hand, and daily life stress reactivity on the other were investigated.