Tracking daily fatigue fluctuations in multiple sclerosis: ecological momentary assessment provides unique insights

Daniel Powell, Christina Liossi, Wolff Schlotz, Rona Moss-Morris
Aberdeen Health Psychology Group
Studies investigating the prevalence, cause, and consequence of multiple sclerosis (MS) fatigue typically use single measures that implicitly assume symptom-stability over time, neglecting information about if, when, and why severity fluctuates. We aimed to examine the extent of moment-to-moment and day-to-day variability in fatigue in relapsing-remitting MS and healthy individuals, and identify daily life determinants of fluctuations.